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SCHIZOPHRENIA: CLUES TO A CAUSE
For 100 years, scientists have searched vainly for schizophrenia’s cause. Today, some contend that it results from a chemical imbalance in the brain. But they have yet to identify a specific chemical mistake. Scientists have, however, pinpointed one chemical defect in the brain that does not cause schizophrenia but might cause some of its symptoms. The problem lies in a faulty dopamine system. Dopamine is one of numerous chemicals in the brain that pass between the ends of nerves, allowing them to signal one another.
Dr. Arnold J. Friedhoff, director of the Millhauser Laboratories at New York University Medical School in Manhattan, has concluded that a healthy dopamine system allows us to manage mental stress. If we face severe stress, such as entering a new job or school, the brain lowers the dopamine signals to help us cope. But, when stressed, most schizophrenics’ nerves are not quieted by their dopamine systems. Their brains go into overdrive; thoughts rush in and out from all directions; they hear sick voices.
Sarah and Harold Edwards of Syracuse, New York, have a son, Ben, who has been sick for 11 years. Ben, now 29, believes there is something like a computer in his head that tells him what to do. “All his past thoughts and present experience merge in a mental logjam,” says Mrs. Edwards. “He’s bored, scared, and angry. And he can’t work or think.”
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